shingleton lab

integrative developmental biology


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41. Harrison, J.F., Shingleton, A.W., Callier, V. 2014. Stunted by developing in hypoxia: Linking comparative and model organism studies. In revision

40. Stillwell, R.C., Shingleton, A.W, Dworkin, I., Frankino, W.A. 2014. Tipping the scales: Evolution of the allometric slope independent of average trait size. In revision.

39. Gokhale, R.H., Shingleton, A.W. 2014. Size Control. WIRE: Developmental Biology. In revision.

38. Mirth, C. K., Shingleton, A.W. 2014. Interacting to control size: the roles of juvenile hormone, insulin/Target Of Rapamycin and ecydsone signalling in regulating body size in Drosophila. Communicative and Integrative Biology. In press.

37. Koyama, T., Rodrigues, M.A., Athanasiadis, A., Shingleton, A.W., Mirth, C.K. 2014. Nutrition regulates body size through FoxO-Ultraspiracle mediated ecdysone synthesis. eLife. In press.

36. Oliveria, M.M., Shingleton, A.W., Mirth, C.K. 2014. Coordination of wing and whole-body development at developmental milestones ensures robustness against environmental and physiological perturbations. PLoS Genetics. 10(6): e1004408

35. Mirth, C.K., Tang, H., Makohon-Moore, S., Salhadar, S., Gokhale, R.H., Riddiford, L.M., Shingleton, A.W. 2014. Juvenile hormone regulates body size and perturbs insulin-signaling in Drosophila. Proceedings of the National Academy of Sciences, USA, doi: 10.1073/pnas.1313058111
See also a commentary on this paper on ScienceNow and IFL Science.


34. Callier, V., Shingleton, A.W., Brent, C.S., Ghosh, S.M., Kim, J., Harrison, J.F., 2013. The role of reduced oxygen in the developmental physiology of growth and metamorphosis initiation in Drosophila melanogaster. The Journal of Experimental Biology, 216, 4334-4340.
Short listed for JEB's "Outstanding Paper Prize 2013". See also "How big is enough: O2'S role in sensing body size", JEB, 216:ii.

33. Nijhout, H.F., Riddiford, L.M., Mirth, C., Shingleton, A.W., Suzuki, Y. Callier, V. 2013, The developmental control of size in insects. WIRE: Developmental Biology, 3, 113-134.

32. Kültz, D., Clayton, D.F., Robinson, G.E., Albertson, C., Carey, H.V., Cummings, M.E., Dewar, K., Edwards, S.V., Hofmann, H.A., Gross, L.J., Kingsolver, J.G., Meaney, M.J., Schlinger, B.A., Shingleton, A.W., Sokolowski, M.B., Somero, G.N., Stanzione, D.C., Todgham, A.E. 2013. New frontiers for organismal biology. BioScience, 63, 464-471.

31. Ghosh, S.M., Testa, N.D., Shingleton, A.W. 2013. Tempertature Size Rule is mediated by thermal plasticity of critical size in Drosophila melanogaster. Proceedings of the Royal Society, London. Series B, 280, no 1760.

30. Bates, P.W., Liang, Y., Shingleton, A.W. 2013. Growth regulation and the insulin-signaling pathway. Networks and Heterogeneous Media, 8 (1), 65-78.

29. Testa, N.D., Ghosh, S.M., Shingleton, A.W. 2013. Sex-specific weight loss mediates sexual size dimorphism in Drosophila melanogaster. PLoS One, 8(3): e58936.

28. Shingleton, A.W., Frankino, W.A. 2013. New perspectives on the evolution of exaggerated traits. BioEssay, 35, 100-107


27. Shingleton, A.W., Tang, H.Y. 2012. Plastic flies: The regulation and evolution of trait variability in Drosophila. Fly, 6, 1-3

26.Mirth, C.K., Shingleton, A.W. 2012. Intergrating body and organ size in Drosophila: recent advances and outstanding problems. Frontiers in Experimental Endocrinology, 3:49


25. Dreyer, A.P., Shingleton, A.W. 2011. The effect of genetic and environmetal variation on genital size in male Drosophila: Canalized but developmentally unstable. PLoS One, 6, e28278

24. Tang, H., Smith-Caldas, M.S.R., Driscoll, M.V., Salhadar, S. & Shingleton, A.W. 2011. FOXO regulates organ-specific phenotypic plasticity in Drosophila. PLoS Genetics, 7, e1002373
See also report in ScienceDaily, "Headline Science: Environmental Sensitivity of Body Parts" in Science Teacher and "Research Highlights: Plastic Flies" in Nature Review Genetics. Listen to a radio interview spot about our research, here, and an NPR 'Academic Minute" spot, here

23. Parker, N.F. & Shingleton, A.W. 2011. The coordination of growth among Drosophila organs in response to localized growth perturbation. Developmental Biology, 357, 318-325

22. Stillwell, R.C., Dworkin, I.M., Shingleton, A.W., Frankino. W.A. 2011. Experimental manipulation of body size to estimate morphological scaling relationships in Drosophila. Journal of Visualized Experiments, e3162

21. Shingleton, A.W. 2011. The regulation and evolution of growth and body size. in "Mechanisms of Life History Evolution" (T. Flatt & A. Heyland, Eds), OUP


20.Shingleton, A.W. 2010. Allometry. Nature Education Knowledge, 1(9):2

19. Shingleton, A.W. 2010. The regulation of organ size in Drosophila: Physiology, plasticity, patterning and physical force. Organogenesis, 6, 1-12


18. Shingleton, A.W., Estep, C.M., Driscoll, M.V., Dworkin, I. 2009. Many ways to be small: Different environmental regulators of size generate different scaling relationships in Drosophila melanogaster. Proceedings of the Royal Society, London. Series B, 276, 2625-2633

17. Frankino, W.A., Emlen, D.J. & Shingleton, A.W. 2009. Experimental approaches to studying the evolution of morphological allometries: The shape of things to come. in "Experimental Evolution" (T. Garland & M.R. Rose, Eds), University of California Press, Berkley.

16. Ramakrishnan, J., Shingleton, A., Reeves, D. Key, J.M., Vural, E. 2009. The effects of molar tooth involvement in mandibular angle fractures treated with rigid fixation. Otolaryngology-Head and Neck Surgery, 140, 845-848


15. Stieper, B.C., Kupershtok, M., Driscoll, M.V. & Shingleton, A.W. 2008. Imaginal disc growth regulates the timing of metamorphosis in Drosophila melanogaster. Developmental Biology, 321, 18-26
See also "Editors' Choice", Science, 321, 12

14. Shingleton, A.W., Mirth, C.K. & Bates, P.W. 2008. Developmental model of static allometry in holometabolous insects. Proceedings of the Royal Society, London. Series B, 275, 1875-1885

13. Vural, E. Winfield, H.L., Shingleton, A.W., Horn, T.D. & Shaferstein, G. 2008. The effect of laser irradition on Trichophyton rubrum growth, Lasers in Medical Science, 23, 349-353


12. Shingleton, A.W., Frankino, W.A., Flatt, T. Nijhout, H.F. & Emlen, D.J. 2007. Size and Shape: The regulation of static allometry in insects, BioEssays, 29 (6), 536-548


11. Shingleton, A.W. 2005, Body-Size Regulation: Combining Genetics and Physiology, Current Biology, 15 (20), R825-R827

10. Shingleton, A.W., Das, J., Vinicius, L. & Stern, D.L. 2005. The temporal requirements for insulin signaling during development in Drosophila, PLoS Biology, 3 (9)
See also "Research Highlights: Sizing up the fly", Nature Reviews Genetics, 6, 802

9. Shingleton, A.W., Stern, D.L. & Foster, W.A. 2005. The origin of a mutualism: a morphological trait promoting the evolution of ant-aphid mutualisms, Evolution, 59 (4), 921-926
A Faculty of 1000 "must read"


8. Shingleton, A.W., Sisk, G.C., & Stern, D.L. 2003. Diapause in the pea aphid (Acyrthosiphon pisum) is a slowing but not a cessation of development, BMC Developmental Biology, 3 (7)

7. Braendle, C., Miura, T., Bickel, R., Shingleton, A.W., Kambhampati, S., Stern, D.L. 2003. Developmental origin and evolution of bacteriocytes in the aphid-Buchnera symbiosis, PLoS Biology, 1, 70-76

6. Miura, T., Braendle, C., Shingleton A.W., Sisk, G., Kambhampati, S. & Stern, D.L. 2003. Comparison of the parthenogenetic and sexual embryogenesis of the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea), Journal of Experimental Zoology, Part B: Molecular and Developmental Evolution, 295B, 59-81.

5. Braendle, C., Hockley, N., Brevig, T., Shingleton, A.W., Keller, L. 2003. Size-correlated division of labour and spatial distribution of workers in the driver ant, Dorylus molestus, Naturwissenschaften, 90, 277-281

4. Shingleton A.W. & Stern, D.L. 2003. Molecular phylogenetic evidence for multiple gains or losses of ant mutualism within the aphid genus Chaitophorus, Molecular Phylogenetics and Evolution, 26, 26-35.


3. Shingleton, A.W. & Foster, W.A. 2001. Behaviour, morphology and the division of labour in two soldier-producing aphids. Animal Behaviour, 62, 671-67

2. Fischer, M.K. & Shingleton, A.W. 2001. Host plant and ants influence the honeydew sugar composition of aphids. Functional Ecology, 15, 544-550.


1. Shingleton, A.W. & Foster, W. A. 2000. Ant tending influences soldier production in a social aphid. Proceedings of the Royal Society, London. Series B, 267, 1863-1868.