peer-reviewed publications

Flies, A. S., Mansfield, L. S., Grant, C. K., Weldele, M. L., and Holekamp, K. E. 2014. Markedly elevated antibody responses in wild versus captive spotted hyenas show that environmental and ecological factors are important modulators of immunity. in preparation.

Flies, A. S., Maksimoski, M. T., Mansfield, L. S., and Holekamp, K. E. 2014. Characterization of toll-like receptors 1–10 in spotted hyenas. Veterinary Research Communications. doi: 10.1007/s11259-014-9592-3.

Johnston, E., Weinstein, P., Slaney, D., Flies, A. S., Williams, C.R. 2014. Mosquito communities with trap height and rural-urban gradient in Adelaide, South Australia: implications for disease vector surveillance. Journal of Vector Ecology.

Nelson, K.G., Engh, A. L., McKnight, C. A., Kiupel, M, Wise, A G., Maes, R. K., Stevens, H, Heylen, E, De Keyser, K, Rector, A, Van Ranst, M, Flies, A. S., and Holekamp, Kay E. 2013. Papillomavirus-associated Cutaneous Papillomas in a Population of Wild Spotted Hyenas (Crocuta crocuta). Journal of Wildlife Diseases. 49, 620-627. doi: 10.7589/2011-09-262

Flies, A. S., Grant, C. K., Mansfield, L. S., Smith, E. J., Weldele, M. and Holekamp, K. E. 2011. Development of a hyena immunology toolbox. Veterinary Immunology and Immunopathology. 145, 110-119, doi:10.1016/j.vetimm.2011.10.016.

Azuma, T., Yao, S., Zhu, G., Flies, A. S. , Flies, S. J. and Chen, L. 2008. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 111:3635-3643. doi: 10.1182/blood-2007-11-123141.

Zhu, G., Augustine, M. M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A. C., Huang, J., Xu, H., Flies, A. S. and Chen, L. 2008. B7-H4 deficient mice display augmented neutrophil-mediated innate immunity. Blood. 113:1759-1767. doi: 10.1182/blood-2008-01-133223.

Goldberg, M. V., Maris, C. H., Hipkiss, E. L., Flies, A. S. , Zhen, L., Tuder, R. M., Grosso, J. F., Harris, T. J., Getnet, D., Whartenby, K. A., Brockstedt, D. G., Dubensky, T. W., Chen, L., Pardoll, D. M. and Drake, C. G. 2007. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 110:186-192. doi: 10.1182/blood-2006-12-062422.

Tsushima, F., Yao, S., Shin, T., Flies, A. S., Flies, S., Xu, H., Tamada, K., Pardoll, D. and Chen, L. 2007. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 110:180. doi: 10.1182/blood-2006-11-060087.

Xu, Y., Flies, A. S. , Flies, D. B., Zhu, G., Anand, S., Flies, S. J., Xu, H., Anders, R. A., Hancock, W. W., Chen, L. and Tamada, K. 2007. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109:4097-4104. doi: 10.1182/blood-2006-09-047332.

Zhu, Y., Zhu, G., Luo, L., Flies, A. S. and Chen, L. 2007. . Blood. 109:4882-4889. doi: 10.1182/blood-2006-10-043463. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

Anand, S., Wang, P., Yoshimura, K., Choi, I., Hilliard, A., Chen, Y., Wang, C., Schulick, R., Flies, A. S. , Flies, D. and Chen, L. 2006. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. Journal of Clinical Investigation. 116:1045-1051. doi: 10.1172/JCI27083.

Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y. and Chen, L. 2004. B7-H3 Enhances Tumor Immunity In Vivo by Costimulating Rapid Clonal Expansion of Antigen-Specific CD8+ Cytolytic T Cells. The Journal of Immunology. 173:5445-5450.

general interest media

Notes from Kenya: MSU Hyena Research

2009. Interview in In Vitro Magazine Click here for pdf

2009. MSU Alumni Magazine feature of the Hyena Research Project Click here for pdf

2007. Disease Ecology and Immunology of the Spotted Hyena - The Vector, Vol. 1 Issue 3. Oct. 2007 Click here for pdf

2007. MSU Fisheries and Wildlife Spotlight Magazine - Tsao Lab: Disease Ecology and Conservation Medicine Click here for pdf