Postdoctoral Training:
Nutritional Immunology, 1999-2001, USDA/HNRCA at Tufts University, Boston, MA
Research Interests: 
Nutritional biochemistry, Nutritional Immunology, obesity, diabetes, energy metabolism
Teaching Interests:  
Nutritional Immunology, Nutrition regulation of gene expression, Metabolism of lipids and carbohydrates.

Undergraduate Advising: Nutritional Sciences 

Graduate Advising:  Human Nutrition 

Publications:

Janette M. Harkins, Naima Moustaid-Moussa, Yong-Joo Chung, Kristen M. Penner James J. Pestka, Colin M. North, and Kate J. Claycombe, Expression of Interleukin-6 is Greater in Preadipocytes than in A dipocytes of 3T3-L1 cells and C57BL/6J and ob/ob Mice, In press, October, J Nutr. 2004.

Wang Y, Jones Vov B, Urs S, Kim S, Soltani-Bejnood M, Quigley N, Heo YR, Standridge M, Andersen B, Dhar M, Joshi R, Wortman P, Taylor JW, Chun J, Leuze M, Claycombe K, Saxton AM, Moustaid-Moussa N, The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. J Nutr. 2004, 134(5):1032-1038.

Heo YR, Claycombe K, Jones BH, Wright P, Truett GE, Zemel M, Banz W, Maher M, Moustaid-Moussa N Effects of fatty (fa) allele and high-fat diet on adipose tissue leptin and lipid metabolism. Horm Metab Res. 2002, 34(11-12):686-690.

Wu D, Marko M, Claycombe K, Paulson KE, Meydani SN, Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated throgh upregulation of NF- kappa B activity.
J Biol Chem. 2003 278(13):10983-92.

Claycombe KJ, Wu D, Nikolova-Karakashian M, Palmer H, Beharka A, Paulson KE, Meydani SN, Ceramide me diates age-associated increase in macrophage cyclooxygenase-2 expression. J Biol Chem. 2002 Aug 23,277(34):30784-91.

Kim s, Whelan J, Claycombe K, Reath DB, Moustaid-Moussa N, Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism J Nutr. 2002 Jun;132(6):1135-40.

Koga T, Claycombe K, Meydani M, Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells. Atherosclerosis. 2002 Apr;161(2):365-74.

Kim S, Dugail I, Standridge M, Claycombe K, Chun J, Moustaid-Moussa N, Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene:role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c Biochem J. 2001 Aug 1;357(Pt3):899-904.

Claycombe KJ, Meydani SN, Vitamin E and genome stability. Mutat Res. 2001 Apr18;475(1-2):37-44. Review.

Claycombe KJ, Wang Y, Jones BH, Kim S, Wilkison WO, Zemel MB, Chun J, Moustaid-Moussa N, Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulin. Physiol Genomics. 2000 Sep8;3(3):157-62.

Claycombe KJ, Xue BZ, Mynatt RL, Zemel MB, Moustaid-Moussa N, Regulation of leptin by agouti. Physiol Genomics. 2000 Apr 27;2(3):101-5.

Moussa NM, Claycombe KJ, The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity. Obes Res. 1999 Sep;7(5):506-14.

Jones BH, Standridge MK, Claycombe KJ, Smith PJ, Moustaid-Moussa N, Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes. Biochem J. 1998 Oct 15;335 ( Pt 2):405-8.

 Claycombe KJ, Jones BH, Standridge MK, Guo Y, Chun JT, Taylor JW, Moustaid-Moussa N, Insulin increases fatty acid synthase gene transcription in human adipocytes. Am J Physiol. 1998 May;274(5 Pt 2):R1253-9.

 Mancuso P, Whelan J, DeMichele SJ, Snider CC, Guszcza JA, Claycombe KJ, Smith GT, Gregory TJ, Karlstad MD, Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. Crit Care Med. 1997 Mar;25(3):523-32.

Claycombe KJ, Lee DW, Miller HA 3^rd, Proportions of rat ANP-secreting cells that are cardiomyocytes and that synthesize the hormone. Am J Physiol. 1995 Jan;268(1 Pt 2):H265-70.