Genetics, adolescent fatness and fitness as predictors of adult metabolic syndrome

 In this study, we are addressing if adolescent growth is related to subsequent adult disease by following subjects from the Saskatchewan Growth and Development Study (SGDS, 1964-1973) who are now approaching the age of 50 years of life, which is about the time that the clinical manifestations of CVD and type 2 diabetes occurs.  Given the longitudinal design of the SGDS we can also investigate the influence of longitudinal growth trajectories during adolescence on adult health outcomes; unlike cross-sectional associations between one-time adolescent and adult measures used in previous studies, the proposed study design allows us to calculate growth trajectories which incorporate change over the entire period. This work will identify potential antecedents in early life that affect the metabolic syndrome. 

Funding for this project is from the Canadian Institutes of Health Research (Co-investigator with Dr. Adam Baxter-Jones, University of Saskatchewan).